Cagrilintide

Cagrilintide Overview

Cagrilintide is a synthetic, long-acting analog of the naturally occurring peptide amylin. It is studied in laboratory and preclinical models for its ability to activate target receptor pathways, contributing to the characterization of endocrine and neuroendocrine signaling. Research has examined its role in modulating downstream signaling cascades, receptor binding kinetics, and systemic pathway dynamics.

Granhall C. et al. (2019).

History

Research into amylin biology began in the late 20th century with its identification as a pancreatic peptide co-secreted with insulin. Native amylin was found to activate specific receptor pathways but was limited by rapid degradation. Cagrilintide was later developed as a stabilized analog with prolonged target activity, providing a research tool for studying calcitonin receptor family signaling and endocrine cross-talk in experimental systems.

Bergmann N.C. et al. (2019).

Cagrilintide Structure

CAS #:

1415456-99-3

Molecular Formula:

C₂₉₄H₄₆₆N₈₄O₈₈S₂

Molecular Weight:

6781.6 g/mol

PubChem ID:

137465331