GHK-Cu

GHK-Cu Overview

GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring copper-binding tripeptide studied for its role in molecular signaling, matrix remodeling, and pathway dynamics. In laboratory and preclinical models, GHK-Cu has been associated with modulation of gene expression, angiogenesis, and extracellular matrix activity, making it a valuable tool for research into experimental biology.

Pickart L. et al. (2015).

History

GHK was first identified in the 1970s in biological plasma samples, where it was observed to decline with age. Subsequent research demonstrated that complexing GHK with copper enhanced its biological activity, particularly in processes related to extracellular matrix dynamics and molecular remodeling. Over the years, GHK-Cu has been extensively studied in models of epithelial biology, angiogenesis, and systemic regulation of gene expression.

Pickart L., Margolina A. (2018).

GHK-Cu Structure

CAS #:

89030-95-5

Molecular Formula:

C₁₄H₂₄CuN₆O₄

Molecular Weight:

340.9 g/mol

PubChem ID:

5311476