Hexarelin

Hexarelin Overview

Hexarelin functions as a multi-pathway peptide agonist influencing endocrine signaling, downstream cascades, and vascular responses through multiple target receptor pathways. As a synthetic hexapeptide secretagogue-type compound that acts as a potent agonist with enhanced stability and potency compared to natural ligands, Hexarelin demonstrates broad signaling activity. Research models examine Hexarelin's effects on pulsatile dynamics, downstream pathway stimulation, vascular signaling, and endocrine modulation in laboratory and preclinical experimental settings, with particular interest in its vascular and systemic actions.

Xu et al. (2014).

History

Hexarelin was developed in the 1990s as part of systematic research into secretagogue-type peptides, following the identification of GHRP-6 and other early compounds in this class. Synthesized to optimize signaling potency and duration of action, Hexarelin emerged as one of the most potent synthetic secretagogue compounds. Subsequent research revealed its unexpected vascular signaling effects independent of the somatotroph axis, leading to expanded investigation of its vascular pathway applications.

Granata et al. (2014).

Hexarelin Structure

CAS #:

140703-51-1

Molecular Formula:

C₄₇H₅₈N₁₂O₆

Molecular Weight:

887.04 g/mol

PubChem ID:

6918245