PT-141

PT-141 Overview

PT-141, also known as Bremelanotide, is a synthetic peptide analog of α-melanocyte-stimulating hormone (α-MSH). It is studied in laboratory and preclinical models for its ability to activate melanocortin receptors (MC3R and MC4R), which are involved in neuroendocrine signaling, energy regulation, and vascular pathways.

Dorr R.T. et al. (1996).

History

PT-141 was developed through research into melanocortin-class peptides, originally derived from modifications of Melanotan II. While Melanotan II was primarily studied for its pigmentation pathway properties, PT-141 was synthesized to focus on central target receptor activity. Since its discovery, PT-141 has been investigated in models of neuroendocrine function, vascular signaling, and peptide-receptor dynamics.

Shadiack A.M. et al. (2002).

PT-141 Structure

CAS #:

189691-06-3

Molecular Formula:

C₅₀H₆₈N₁₄O₁₀

Molecular Weight:

1025.2 g/mol

PubChem ID:

6918280