Thymosin Alpha 1

Thymosin Alpha 1 Overview

Thymosin Alpha 1 functions as a potent immunomodulator that influences signaling dynamics, cytokine expression, and immune pathway homeostasis. As a naturally occurring 28-amino acid peptide originally isolated from thymic tissue, Tα1 has been studied for its role in thymocyte signaling, immune pathway differentiation, and innate and adaptive response regulation. Through toll-like receptor (TLR) pathway activation and signaling modulation, Tα1 has been investigated in research models examining thymocyte dynamics, dendritic signaling, natural killer pathway activity, and multi-system immune responses in laboratory settings. Liu et al. (2023).

Romani et al. (2007).

History

Thymosin Alpha 1 was first isolated and characterized from bovine thymus gland in the 1970s by Allan Goldstein and colleagues at George Washington University. This peptide was identified as the primary active component of thymosin fraction 5, a crude thymic extract with immunological activity. Subsequent research established its role in thymocyte differentiation and led to development as thymalfasin for continued experimental investigation.

Goldstein et al. (2010).

Thymosin Alpha 1 Structure

CAS #:

62304-98-7

Molecular Formula:

C₁₂₉H₂₁₅N₃₃O₅₅

Molecular Weight:

3108.28 g/mol

PubChem ID:

16132341