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DP3-R is a synthetic investigational peptide developed as a multi-receptor agonist. It is currently being studied for its potential effects on receptor-mediated signaling, cellular metabolism, and endocrine function in preclinical research models. By activating multiple incretin and glucagon receptors, DP3-R demonstrates broad systemic effects under investigation for their relevance in metabolic and endocrine research.
The development of DP3-R builds on decades of research into incretin-based peptide science. Early studies with single receptor agonists established their role in downstream signaling and receptor activity. Subsequent research expanded to dual agonist frameworks, paving the way for DP3-R, which uniquely integrates three receptor targets. This multi-agonist design reflects a new direction in peptide research aimed at investigating broader receptor-mediated modulation in preclinical laboratory settings.
DP3-R Structure

CAS #: 2381089-83-2
Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight: 4845.44 g/mol
PubChem ID: 474492335
DP3-R has been examined in metabolic and systemic models, with studies highlighting its influence on glucose regulation, insulin signaling, lipid metabolism, and integrated hormone pathways. Research also points to its role in energy balance and multi-system signaling in preclinical and laboratory settings.
Key Areas of Research:
• Metabolic: Glucose, insulin, energy regulation
• Endocrine: GLP-1, GIP, glucagon pathways
• Cardiovascular: Lipid, cholesterol, hepatic signaling
• Systemic: Multi-hormone signaling, resilience, balance
Together, these findings suggest broad experimental potential for DP3-R across endocrine, cardiovascular, and systemic models. By engaging multiple receptor pathways, it provides a versatile research platform for studying downstream signaling cascades and integrated cellular responses across diverse biological systems.
Jastreboff A.M. et al., New England Journal of Medicine, 2023





