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MOTS-c is a 16–amino acid peptide encoded in the mitochondrial genome, studied for its role in cellular metabolism and mitochondrial signaling pathways.
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Frequently asked questions
MOTS-c was first described in 2015 following the discovery of short open reading frames encoded within mitochondrial DNA. Identified as a peptide regulator of metabolic signaling, it has since been studied for its ability to activate AMP-activated protein kinase (AMPK) pathways and support cellular stress resistance. This discovery expanded the understanding of mitochondria as signaling organelles beyond energy production, positioning MOTS-c as a key peptide in mitochondrial biology research.
MOTS-c
CAS #: 1627580-64-6
Molecular Formula: C₁₄₉H₂₆₀N₄₆O₄₆S₂
Molecular Weight: 2171.5 g/mol
PubChem ID: 91808068
MOTS-c has been studied in metabolic, cellular, and systemic models, with research highlighting its role in mitochondrial function, energy regulation, and metabolic balance. Studies also report activity in glucose utilization, insulin sensitivity, and cellular stress responses in preclinical settings.
Key Areas of Research:
• Metabolic: glucose, insulin, energy balance
• Cellular: mitochondrial function, stress response, repair
• Systemic: protection, recovery, resilience8
Together, these findings suggest broad experimental potential for MOTS-c across metabolic, cellular, and systemic pathways. By engaging mitochondrial biology and modulating energy and stress responses, MOTS-c provides a versatile platform for research into metabolic regulation, cellular recovery, and systemic health in laboratory models.
