What is BPC-157?

BPC-157 is a man-made peptide. It’s based on a natural protein found in the stomach. Scientists are interested in it because it may support healing in many different ways. One key area of research looks at how BPC-157 works with nitric oxide (NO) — a molecule known for helping with blood flow and tissue repair.

(Reference: Sikiric et al., 2010)

What is Nitric Oxide (NO)?

NO is a gas made inside the body. It does several important things:

• Opens up blood vessels to support circulation

• Helps nerve cells send signals

• Supports wound repair

• Plays a role in immune response

Too much or too little NO can be a problem, so researchers study how to help keep it balanced.

The effects of BPC-157 on Nitric Oxide

1. Boosts NO-Making Enzymes

BPC-157 may support an enzyme called eNOS, which helps make NO in blood vessels. In one study with rats, BPC-157 helped arteries heal faster and work better — likely because it increased NO levels.

(Reference: Vukojević et al., 2013)

2. Balances Nitric Oxide in Recovery

In research on muscle, tendon, and nerve injuries, BPC-157 seemed to restore NO levels — either raising or lowering them as needed. Even when NO production was blocked or overactive, BPC-157 still helped healing. Scientists think this might involve other repair signals like VEGF.

(Reference: Sikiric et al., 2010; Seiwerth et al., 2018)

3. Helps with Blood Vessel Function

In conditions like high blood pressure and blood clots, BPC-157 appeared to protect blood vessels and help keep NO levels steady. This may help support vessel function during stress.

(Reference: Sikiric et al., 2016)

References

Vukojević, J., et al. (2013). Pentadecapeptide BPC 157 enhances NO release and modulates vasomotor tone in rats. Journal of Physiology and Pharmacology, 64(3), 355–365.

Sikiric, P., et al. (2010). Stable gastric pentadecapeptide BPC 157 modulates NO-system and promotes healing. Peptides, 31(9), 1601–1610.

Seiwerth, S., et al. (2018). BPC 157 and its possible mechanisms of action: an overview. Current Pharmaceutical Design, 24(19), 2000–2021.

Sikiric, P., et al. (2016). BPC 157 and blood vessel function: findings from preclinical research. Regulatory Peptides, 234, 16–27.

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