What is Cagrilintide?

Cagrilintide is a lab-made peptide based on amylin, a naturally occurring peptide that works with insulin. It’s being studied for how it may affect hunger, fullness, and energy balance. One key area of research looks at how cagrilintide signals to the brain to help control how much is eaten and how fast food moves through the stomach.

What is Amylin?

Amylin is a peptide involved in:

• Slowing how fast food leaves the stomach

• Helping the brain feel full after eating

• Keeping blood sugar more stable after meals

• Helping manage long-term energy intake

Because regular amylin breaks down quickly, researchers developed longer-lasting versions like cagrilintide to study these effects more easily.

How Cagrilintide is Being Studied:

1. Effects on Appetite Receptors

Cagrilintide works on brain receptors linked to appetite. In one study, researchers found that it helped test subjects feel fuller and eat less compared to a control group.

(Reference: Lau et al., 2021)

2. Slows Down Gastric Emptying

Cagrilintide has been shown to slow down how quickly food leaves the stomach. This effect has been linked to better appetite control and steadier energy levels in research settings.

(Reference: Lau et al., 2021)

3. Works Well with GLP-1 Analogs

Scientists are also studying cagrilintide with GLP-1 peptides like semaglutide. Early results suggest the combo may have stronger effects on appetite and energy use than either one alone.

(Reference: Knudsen et al., 2022)

References

• Lau, D.C.W., et al. (2021). Once-weekly cagrilintide for weight management in people with overweight and obesity: a randomized, double-blind, placebo-controlled, dose-finding phase 2 trial. The Lancet, 397(10290), 1736–1748.

• Knudsen, L.B., et al. (2022). Dual hormone co-agonists for treatment of obesity. Trends in Molecular Medicine, 28(4), 300–314.

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